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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Acc ID: CHEBI:9163
Term: Sinomenine
Definition: A morphinane alkaloid that has formula C19H23NO4.
Chemical ID: MESH:C009271
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cbmultiple interactionsISOPIK3CB (Homo sapiens)6480464CTDsinomenine inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased phosphorylation of PIK3CB protein]PMID:37436133
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