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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620897
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dusp1
Name: dual specificity phosphatase 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; SB 203580 inhibits the reaction [Cadmium results in increased expression of DUSP1 protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of DUSP1 mRNA]; SB 203580 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]PMID:11577072 PMID:18573614 PMID:20885979
Dusp1multiple interactionsISODusp1 (Mus musculus)6480464CTDSB 203580 inhibits the reaction [arsenite results in increased expression of DUSP1 mRNA]PMID:11689710
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