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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620897
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dusp1
Name: dual specificity phosphatase 1
Acc ID: CHEBI:4653
Term: dipyridamole
Definition: A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Chemical ID: MESH:D004176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp1increases phosphorylationEXP 6480464CTDDipyridamole results in increased phosphorylation of DUSP1 proteinPMID:19356721
Dusp1multiple interactionsEXP 6480464CTDDUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]PMID:19356721
Dusp1increases phosphorylationISODusp1 (Mus musculus)6480464CTDDipyridamole results in increased phosphorylation of DUSP1 proteinPMID:16765938
Dusp1multiple interactionsISODusp1 (Mus musculus)6480464CTDDUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]PMID:16765938
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