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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp63
Name: tumor protein p63
Acc ID: CHEBI:52722
Term: lactacystin
Definition: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
Chemical ID: MESH:C067713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp63multiple interactionsISOTP63 (Homo sapiens)6480464CTDlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]; lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form]PMID:21191146
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