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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pla2g2a
Name: phospholipase A2 group IIA
Acc ID: CHEBI:15627
Term: thromboxane A2
Definition: A thromboxane which is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation.
Chemical ID: MESH:D013928
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pla2g2aincreases abundanceISOPLA2G2A (Homo sapiens)6480464CTDPLA2G2A protein results in increased abundance of Thromboxane A2 metabolitePMID:10027849
Pla2g2amultiple interactionsISOPLA2G2A (Homo sapiens)6480464CTDvarespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane A2 metabolite]PMID:10027849
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