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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620823
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lct
Name: lactase
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lctaffects activityEXP 6480464CTDnimesulide affects the activity of LCT proteinPMID:18604318
Lctdecreases activityEXP 6480464CTDnimesulide results in decreased activity of LCT proteinPMID:16382204
Lctincreases activityEXP 6480464CTDnimesulide results in increased activity of LCT; nimesulide results in increased activity of LCT proteinPMID:16855794 PMID:17147060
Lctmultiple interactionsEXP 6480464CTD[nimesulide results in decreased activity of LCT protein] which results in decreased transport of GlucosePMID:16382204
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