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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bnip3affects splicingISOBnip3 (Mus musculus)6480464CTDEthanol affects the splicing of BNIP3 mRNAPMID:30319688
Bnip3decreases expressionISOBNIP3 (Homo sapiens)6480464CTDEthanol results in decreased expression of BNIP3 mRNAPMID:28986285
Bnip3increases expressionISOBnip3 (Mus musculus)6480464CTDEthanol results in increased expression of BNIP3 mRNA; Ethanol results in increased expression of BNIP3 proteinPMID:24095927 PMID:30319688
Bnip3multiple interactionsISOBNIP3 (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of BNIP3 mRNAPMID:29432896
Bnip3multiple interactionsISOBnip3 (Mus musculus)6480464CTDDactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]; FOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of BNIP3 mRNA]PMID:24095927
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