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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620784
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf11
Name: TNF superfamily member 11
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf11decreases activityISOTnfsf11 (Mus musculus)6480464CTDQuercetin results in decreased activity of TNFSF11 proteinPMID:19495926
Tnfsf11multiple interactionsISOTnfsf11 (Mus musculus)6480464CTDQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]PMID:16434028 PMID:19495926
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