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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620713
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgfr1
Name: Fibroblast growth factor receptor 1
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgfr1increases expressionEXP 6480464CTDTriiodothyronine results in increased expression of FGFR1 mRNA; Triiodothyronine results in increased expression of FGFR1 proteinPMID:12805413
Fgfr1multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]PMID:12805413
Fgfr1increases expressionISOFgfr1 (Mus musculus)6480464CTDTriiodothyronine results in increased expression of FGFR1 mRNAPMID:16150908
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