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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:7852
Term: oxycodone
Definition: A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.
Chemical ID: MESH:D010098
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene polymorphism affects the susceptibility to OxycodonePMID:20590588
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to OxycodonePMID:20590588
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