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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12amultiple interactionsISOIL12A (Homo sapiens)6480464CTDarsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL12A mRNA]; arsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of [IL12B protein binds to IL12A protein]]; arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]; arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]; NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]PMID:25680285
Il12amultiple interactionsISOIl12a (Mus musculus)6480464CTDarsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]; NFE2L2 gene mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]PMID:25680285
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