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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1decreases phosphorylationISOChek1 (Mus musculus)6480464CTDZearalenone results in decreased phosphorylation of CHK1 proteinPMID:34716709
Chek1increases expressionISOChek1 (Mus musculus)6480464CTDZearalenone results in increased expression of CHEK1 proteinPMID:35504548
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