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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620522
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lmnb1
Name: lamin B1
Acc ID: CHEBI:567361
Term: cladribine
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Chemical ID: MESH:D017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lmnb1increases cleavageISOLMNB1 (Homo sapiens)6480464CTDCladribine results in increased cleavage of LMNB1 proteinPMID:15582267
Lmnb1multiple interactionsISOLMNB1 (Homo sapiens)6480464CTD[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 proteinPMID:15582267
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