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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:5835
Term: hypericin
Definition: A carbopolycyclic compound that has formula C30H16O8.
Chemical ID: MESH:C004965
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2adecreases activityISOTOP2A (Homo sapiens)6480464CTDhypericin results in decreased activity of TOP2A proteinPMID:11597574
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