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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2aaffects expressionISOTOP2A (Homo sapiens)6480464CTDsodium arsenite affects the expression of TOP2A mRNAPMID:29301061
Top2adecreases expressionISOTOP2A (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of TOP2A mRNAPMID:12760830 PMID:32844245 PMID:38568856
Top2aincreases expressionISOTOP2A (Homo sapiens)6480464CTDsodium arsenite results in increased expression of TOP2A mRNAPMID:12016162
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