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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620474
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox9
Name: SRY-box transcription factor 9
Acc ID: CHEBI:2567
Term: alendronic acid
Definition: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Chemical ID: MESH:D019386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox9increases expressionISOSOX9 (Homo sapiens)6480464CTDAlendronate results in increased expression of SOX9 mRNA; Alendronate results in increased expression of SOX9 proteinPMID:33522294
Sox9multiple interactionsISOSOX9 (Homo sapiens)6480464CTDAlendronate inhibits the reaction [TNF protein results in increased expression of SOX9 mRNA]; Alendronate inhibits the reaction [TNF protein results in increased expression of SOX9 protein]; SP1 protein affects the reaction [Alendronate results in increased expression of SOX9 mRNA]; SP1 protein affects the reaction [Alendronate results in increased expression of SOX9 protein]PMID:33522294
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