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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:32181
Term: tamibarotene
Definition: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.
Chemical ID: MESH:C061133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4decreases expressionISOCxcr4 (Mus musculus)6480464CTDtamibarotene results in decreased expression of CXCR4 mRNAPMID:20861477
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTDtamibarotene results in increased uptake of and affects the localization of CXCR4 proteinPMID:20141446
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