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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of CXCR4 mRNAPMID:33354967
Cxcr4decreases expressionISOCXCR4 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of CXCR4 mRNAPMID:28458013
Cxcr4increases expressionISOCXCR4 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of CXCR4 mRNAPMID:28943387
Cxcr4increases expressionISOCxcr4 (Mus musculus)6480464CTDAflatoxin B1 results in increased expression of CXCR4 mRNAPMID:28789997
Cxcr4increases methylationISOCXCR4 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of CXCR4 genePMID:28458013
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTDdecitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of CXCR4 mRNA]PMID:28458013
Cxcr4multiple interactionsISOCxcr4 (Mus musculus)6480464CTD[ITPR3 protein mutant form results in increased susceptibility to Aflatoxin B1] which results in increased expression of CXCR4 mRNA; [ITPR3 protein mutant form results in increased susceptibility to Aflatoxin B1] which results in increased expression of CXCR4 protein; Aflatoxin B1 promotes the reaction [ITPR3 protein mutant form results in increased expression of CXCR4 mRNA]; Aflatoxin B1 promotes the reaction [ITPR3 protein mutant form results in increased expression of CXCR4 protein]PMID:38679149
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