Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of CXCR4 mRNA; Oxygen deficiency results in increased expression of CXCR4 proteinPMID:22745725 PMID:26476374
Cxcr4multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]PMID:26476374
Cxcr4increases expressionISOCXCR4 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of CXCR4 mRNA; Oxygen deficiency results in increased expression of CXCR4 proteinPMID:17476338 PMID:17517823 PMID:25047463 PMID:26516004
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTDarsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]; arsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]PMID:22745725 PMID:25047463
Cxcr4multiple interactionsISOCxcr4 (Mus musculus)6480464CTD[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA; [Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CXCR4 mRNAPMID:18227068 PMID:30529165
Go Back to source page   Continue to Ontology report