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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4increases expressionISOCCL4 (Homo sapiens)6480464CTDPoly I-C results in increased expression of CCL4 mRNAPMID:27783115
Ccl4increases expressionISOCcl4 (Mus musculus)6480464CTDPoly I-C results in increased expression of CCL4 proteinPMID:19500611
Ccl4increases secretionISOCcl4 (Mus musculus)6480464CTDPoly I-C results in increased secretion of CCL4 proteinPMID:24056979
Ccl4multiple interactionsISOCCL4 (Homo sapiens)6480464CTD6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]; [TL8-506 co-treated with Poly I-C] results in increased expression of CCL4 mRNA; [TL8-506 co-treated with Poly I-C] results in increased secretion of CCL4 protein; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]PMID:27783115 PMID:35688559
Ccl4multiple interactionsISOCcl4 (Mus musculus)6480464CTDEthanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]PMID:19500611 PMID:24056979
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