Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDSevoflurane results in decreased expression of NFE2L2 mRNA; Sevoflurane results in decreased expression of NFE2L2 proteinPMID:37041698 PMID:37494465
Nfe2l2multiple interactionsEXP 6480464CTD6,7-dihydroxyflavone inhibits the reaction [TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of NFE2L2 mRNA]]; 6,7-dihydroxyflavone inhibits the reaction [TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of NFE2L2 protein]]; MIR190A inhibits the reaction [Sevoflurane results in decreased expression of NFE2L2 protein]; TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of NFE2L2 mRNA]; TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of NFE2L2 protein]; TBX2 protein promotes the reaction [Sevoflurane results in decreased expression of NFE2L2 protein]PMID:37041698 PMID:37494465
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDSevoflurane affects the localization of NFE2L2 proteinPMID:35430185
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDMAF1 protein affects the reaction [Sevoflurane affects the localization of NFE2L2 protein]PMID:35430185
Go Back to source page   Continue to Ontology report