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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:31401
Term: cilostazol
Definition: A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Chemical ID: MESH:C045645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTDCilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]]PMID:30295103 PMID:32456565
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDcilostazol results in increased expression of NFE2L2 proteinPMID:20131233
Nfe2l2increases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 results in increased susceptibility to cilostazolPMID:20131233
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]PMID:20131233
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