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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo1affects localizationEXP 6480464CTDSimvastatin affects the localization of FOXO1 proteinPMID:19001041
Foxo1decreases phosphorylationEXP 6480464CTDSimvastatin results in decreased phosphorylation of FOXO1 proteinPMID:19001041
Foxo1increases phosphorylationEXP 6480464CTDSimvastatin results in increased phosphorylation of FOXO1 proteinPMID:18826357
Foxo1affects localizationISOFoxo1 (Mus musculus)6480464CTDSimvastatin affects the localization of FOXO1 proteinPMID:33034787
Foxo1decreases localizationISOFOXO1 (Homo sapiens)6480464CTDSimvastatin results in decreased localization of FOXO1 proteinPMID:12438947
Foxo1decreases phosphorylationISOFoxo1 (Mus musculus)6480464CTDSimvastatin results in decreased phosphorylation of FOXO1 proteinPMID:33034787
Foxo1multiple interactionsISOFOXO1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]PMID:12438947
Foxo1multiple interactionsISOFoxo1 (Mus musculus)6480464CTDfarnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]PMID:33034787
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