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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo1affects expressionEXP 6480464CTDbisphenol A affects the expression of FOXO1 mRNAPMID:30816183 PMID:32145629
Foxo1increases expressionEXP 6480464CTDbisphenol A results in increased expression of FOXO1 mRNAPMID:34947998
Foxo1affects methylationISOFoxo1 (Mus musculus)6480464CTDbisphenol A affects the methylation of FOXO1 promoterPMID:27334623
Foxo1increases expressionISOFoxo1 (Mus musculus)6480464CTDbisphenol A results in increased expression of FOXO1 mRNAPMID:32575098 PMID:35569583 PMID:35598803 PMID:36674557
Foxo1multiple interactionsISOFOXO1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of FOXO1 genePMID:31601247
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