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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:17154
Term: nicotinamide
Definition: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical ID: MESH:D009536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1increases phosphorylationISOEIF4EBP1 (Homo sapiens)6480464CTDNiacinamide results in increased phosphorylation of EIF4EBP1 proteinPMID:19928762
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTD[Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Niacinamide inhibits the reaction [Resveratrol results in decreased phosphorylation of EIF4EBP1 protein]PMID:19928762 PMID:20169165
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