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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb1increases phosphorylationISOCREB1 (Homo sapiens)6480464CTDhydroquinone results in increased phosphorylation of CREB1 proteinPMID:23288922
Creb1multiple interactionsISOCREB1 (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [hydroquinone results in increased phosphorylation of CREB1 protein]; CREB1 protein affects the reaction [hydroquinone results in increased expression of PPP2CA protein]; CREB1 protein affects the reaction [hydroquinone results in increased expression of TNF protein]; hydroquinone promotes the reaction [CREB1 protein binds to PPP2CA promoter]PMID:23288922
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