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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDCannabidiol results in increased expression of BECN1 mRNA; Cannabidiol results in increased expression of BECN1 proteinPMID:33244087 PMID:38583854
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTD[PSEN1 protein affects the susceptibility to Cannabidiol] which results in increased expression of BECN1 proteinPMID:33096116
Becn1multiple interactionsISOBecn1 (Mus musculus)6480464CTDCannabidiol inhibits the reaction [DMD gene mutant form results in decreased expression of BECN1 mRNA]PMID:30074247
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