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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionEXP 6480464CTDMethamphetamine results in increased expression of BECN1 proteinPMID:26825372 PMID:31059759 PMID:32035215 PMID:34374793
Becn1increases phosphorylationEXP 6480464CTDMethamphetamine results in increased phosphorylation of BECN1 proteinPMID:32676729
Becn1multiple interactionsEXP 6480464CTDCEBPB protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of BECN1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]PMID:26825372 PMID:31059759 PMID:32035215
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDMethamphetamine results in increased expression of BECN1 proteinPMID:31059759
Becn1increases expressionISOBecn1 (Mus musculus)6480464CTDMethamphetamine results in increased expression of BECN1 mRNA; Methamphetamine results in increased expression of BECN1 proteinPMID:31928234 PMID:33359793 PMID:37567421
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTDDDIT4 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]PMID:31059759
Becn1multiple interactionsISOBecn1 (Mus musculus)6480464CTD6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene inhibits the reaction [Methamphetamine results in increased expression of BECN1 mRNA]; NFE2L2 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; sulforaphane inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]PMID:31928234 PMID:37567421
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