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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1decreases expressionISOBecn1 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of BECN1 proteinPMID:32151603
Becn1increases expressionISOBecn1 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of BECN1 proteinPMID:38348709
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTDBECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]PMID:16896004
Becn1multiple interactionsISOBecn1 (Mus musculus)6480464CTDasperuloside promotes the reaction [Cyclophosphamide results in increased expression of BECN1 protein]; CSF2 protein promotes the reaction [Cyclophosphamide results in increased expression of BECN1 protein]; dorsomorphin inhibits the reaction [asperuloside promotes the reaction [Cyclophosphamide results in increased expression of BECN1 protein]]; dorsomorphin inhibits the reaction [Cyclophosphamide results in increased expression of BECN1 protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein]PMID:32151603 PMID:38348709
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