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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf21
Name: fibroblast growth factor 21
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf21decreases secretionISOFGF21 (Homo sapiens)6480464CTDcobaltous chloride results in decreased secretion of FGF21 proteinPMID:22917661
Fgf21multiple interactionsISOFGF21 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein]; cobaltous chloride results in decreased expression of and results in decreased stability of FGF21 mRNAPMID:22917661
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