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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1multiple interactionsEXP 6480464CTD[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]PMID:30273964
Pon1decreases activityISOPon1 (Mus musculus)6480464CTDCholesterol results in decreased activity of PON1 proteinPMID:16115471
Pon1decreases chemical synthesisISOPON1 (Homo sapiens)6480464CTDPON1 protein results in decreased chemical synthesis of CholesterolPMID:12615663
Pon1decreases chemical synthesisISOPon1 (Mus musculus)6480464CTDPON1 protein results in decreased chemical synthesis of CholesterolPMID:12615663
Pon1increases exportISOPON1 (Homo sapiens)6480464CTDPON1 protein results in increased export of CholesterolPMID:16229851 PMID:16331452
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