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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDSirolimus results in decreased expression of VEGFA proteinPMID:24971338
Vegfamultiple interactionsEXP 6480464CTD[Sirolimus co-treated with Hydrogen Peroxide] results in increased expression of VEGFA mRNAPMID:31332898
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDSirolimus results in decreased expression of VEGFA mRNAPMID:15930297
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]PMID:15050414 PMID:16682453 PMID:17968710 PMID:20554536
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDSirolimus inhibits the reaction [cyanoginosin LR results in increased expression of VEGFA protein]PMID:36115647
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