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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:81758
Term: cyproconazole
Definition: A diastereoisomeric mixture composed of the enantiomeric pair (2R,3S)- and (2S,3R)-cyproconazole in ratio 1:1 with the enantiomeric pair (2R,3R)- and (2S,3S)-cyproconazole. A broad spectrum fungicide, it is used on cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases.
Chemical ID: MESH:C093628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTDcyproconazole results in increased expression of ABCB1A mRNA; cyproconazole results in increased expression of ABCB1A proteinPMID:25182419 PMID:29038839 PMID:33150952
Abcb1amultiple interactionsEXP 6480464CTD[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ABCB1A mRNA; [cyproconazole co-treated with epoxiconazole] results in increased expression of ABCB1A mRNAPMID:29038839
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDcyproconazole results in increased expression of ABCB1A proteinPMID:33150952
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