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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:5134
Term: fluticasone
Definition: A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Chemical ID: MESH:C065382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDFluticasone results in increased expression of ABCB1 proteinPMID:22464980
Abcb1aincreases secretionISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased secretion of FluticasonePMID:22464980
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDElacridar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]PMID:22464980
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