GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | decreases expression | EXP | | 6480464 | CTD | Atorvastatin results in decreased expression of ABCB1A mRNA | PMID:24502637 | Abcb1a | decreases activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Atorvastatin analog results in decreased activity of ABCB1 protein | PMID:15616150 | Abcb1a | increases transport | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 protein results in increased transport of Atorvastatin; ABCB1 protein results in increased transport of Atorvastatin analog | PMID:10751037 PMID:15616150 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM] | PMID:15616150 PMID:19802823 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |