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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:50462
Term: citronellol
Definition: A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7.
Chemical ID: MESH:C007078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDcitronellol results in decreased activity of ABCB1 proteinPMID:15890377
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]PMID:15890377 PMID:16904803
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