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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:50344
Term: avermectin
Definition: Any of the macrolides obtained as fermentation products from the bacterium Streptomyces avermitilis and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties.
Chemical ID: MESH:C019264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein affects the susceptibility to avermectinPMID:10562306
Abcb1adecreases response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in decreased susceptibility to avermectinPMID:9144452
Abcb1aincreases response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A gene mutant form results in increased susceptibility to avermectinPMID:22834856
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