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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDDecitabine results in increased expression of ABCB1 mRNAPMID:27570640
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[[Decitabine co-treated with trichostatin A] affects the methylation of ABCB1 gene] which affects the expression of ABCB1 mRNA; [Decitabine affects the methylation of ABCB1 gene] which affects the expression of ABCB1 mRNA; Decitabine promotes the reaction [trichostatin A results in increased expression of ABCB1 mRNA]PMID:18673531 PMID:27570640
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