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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDTunicamycin results in decreased expression of ABCB1 proteinPMID:34915026
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDTunicamycin results in increased expression of ABCB1 mRNAPMID:29453283
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Tunicamycin results in decreased expression of ABCB1 protein]PMID:34915026
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