GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | decreases response to substance | EXP | | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Dactinomycin | PMID:11455017 | Abcb1a | multiple interactions | EXP | | 6480464 | CTD | Dactinomycin inhibits the reaction [[Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [[Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Dactinomycin inhibits the reaction [tetrabromobisphenol A results in increased expression of and results in increased activity of ABCB1A protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] | PMID:18474546 PMID:20410605 PMID:30830211 | Abcb1a | decreases response to substance | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Dactinomycin | PMID:15725475 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCB1 mRNA] | PMID:1967174 PMID:19813763 | | ||||||||||||||||||||||
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