Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619951
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Abcb1a
Name:	ATP binding cassette subfamily B member 1A

Acc ID:	CHEBI:15365
Term:	acetylsalicylic acid
Definition:	A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID:	MESH:D001241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Abcb1a	increases expression	EXP		6480464	CTD	Aspirin results in increased expression of ABCB1 mRNA; Aspirin results in increased expression of ABCB1 protein	PMID:21900887
Abcb1a	multiple interactions	EXP		6480464	CTD	[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel	PMID:21900887
Abcb1a	increases activity	ISO	ABCB1 (Homo sapiens)	6480464	CTD	Aspirin results in increased activity of ABCB1 protein	PMID:19840843
Abcb1a	increases expression	ISO	ABCB1 (Homo sapiens)	6480464	CTD	Aspirin results in increased expression of ABCB1 mRNA; Aspirin results in increased expression of ABCB1 protein	PMID:21900887

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