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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:3090
Term: bicalutamide
Definition: A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Chemical ID: MESH:C053541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenincreases activityISOPTEN (Homo sapiens)6480464CTDbicalutamide results in increased activity of PTEN proteinPMID:16637073
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDbicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA]PMID:16637073
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