GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c6 | affects metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein affects the metabolism of Omeprazole | PMID:14586384 PMID:15286053 PMID:15626586 PMID:16035375 | Cyp2c6 | decreases activity | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | Omeprazole results in decreased activity of CYP2C19 protein | PMID:15306208 PMID:21795468 PMID:21915887 | Cyp2c6 | decreases metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 gene alternative form results in decreased metabolism of Omeprazole | PMID:20573087 | Cyp2c6 | increases hydroxylation | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased hydroxylation of Omeprazole | PMID:12637241 PMID:18511451 PMID:22634058 | Cyp2c6 | increases metabolic processing | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased metabolism of Omeprazole | PMID:11752104 PMID:12464242 PMID:12467917 PMID:12485723 PMID:17565714 PMID:17702393 PMID:8930576 | Cyp2c6 | multiple interactions | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | [5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel] | PMID:11752104 PMID:15258107 PMID:18520598 PMID:19812348 PMID:21277363 PMID:21915887 PMID:26599973 PMID:31515991 PMID:9600717 | | ||||||||||||||||||||||
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