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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:46081
Term: fluconazole
Definition: A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Chemical ID: MESH:D015725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6decreases activityISOCYP2C19 (Homo sapiens)6480464CTDFluconazole results in decreased activity of CYP2C19 proteinPMID:12464242 PMID:15843491 PMID:19328226 PMID:26599973
Cyp2c6increases expressionISOCyp2c29 (Mus musculus)6480464CTDFluconazole results in increased expression of CYP2C29 mRNAPMID:16730040
Cyp2c6increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased metabolism of FluconazolePMID:17702393
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTD[Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of OmeprazolePMID:26599973
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