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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6affects metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein affects the metabolism of ChlorpyrifosPMID:15764407 PMID:16190164 PMID:17079358
Cyp2c6decreases activityISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in decreased activity of ChlorpyrifosPMID:22281205
Cyp2c6decreases expressionISOCYP2C19 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of CYP2C19 proteinPMID:32194361
Cyp2c6increases expressionISOCYP2C19 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CYP2C19 mRNAPMID:16757081 PMID:33011216
Cyp2c6increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 results in increased metabolism of ChlorpyrifosPMID:20709133
Cyp2c6multiple interactionsISOCyp2c29 (Mus musculus)6480464CTD[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA; [Dietary Fats results in increased susceptibility to Chlorpyrifos] which results in decreased expression of CYP2C29 mRNA; [Endosulfan co-treated with Atrazine co-treated with Chlorpyrifos] results in increased expression of CYP2C29 mRNAPMID:22515965 PMID:29935250 PMID:32745781
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