GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gper1 | decreases expression | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in decreased expression of GPER1 mRNA; Tamoxifen results in decreased expression of GPER1 protein | PMID:30153467 PMID:32530119 | Gper1 | decreases response to substance | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | GPER1 protein results in decreased susceptibility to Tamoxifen | PMID:19911269 | Gper1 | increases activity | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | Tamoxifen analog results in increased activity of GPER1 protein | PMID:19549922 | Gper1 | multiple interactions | ISO | GPER1 (Homo sapiens) | 6480464 | CTD | [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein; GPER1 protein affects the reaction [Tamoxifen affects the localization of FOXO3 protein]; GPER1 protein promotes the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; Tamoxifen inhibits the reaction [Quercetin results in increased expression of GPER1 mRNA] | PMID:20211987 PMID:26470790 PMID:30153467 PMID:32530119 | | ||||||||||||||||||||||
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