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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:28689
Term: dehydroepiandrosterone
Definition: An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Chemical ID: MESH:D003687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gper1increases expressionISOGPER1 (Homo sapiens)6480464CTDDehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 proteinPMID:25969534
Gper1multiple interactionsISOGPER1 (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]PMID:25969534
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