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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gper1decreases expressionISOGPER1 (Homo sapiens)6480464CTDnaringenin metabolite results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 proteinPMID:30153467 PMID:36235125
Gper1multiple interactionsISOGPER1 (Homo sapiens)6480464CTD[Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 proteinPMID:30153467
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