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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grb2
Name: growth factor receptor bound protein 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grb2increases expressionEXP 6480464CTDOzone results in increased expression of GRB2 proteinPMID:33146391
Grb2multiple interactionsISOGRB2 (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which affects the expression of GRB2 mRNA; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of GRB2 mRNAPMID:32992648 PMID:35430440
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