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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619572
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC22A6
Name: solute carrier family 22 member 6
Acc ID: CHEBI:15640
Term: 5-formyltetrahydrofolic acid
Definition: A formyltetrahydrofolic acid in which the formyl group is located at position 5.
Chemical ID: MESH:D002955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC22A6increases uptakeEXP 6480464CTDSLC22A6 protein results in increased uptake of LeucovorinPMID:16098483
SLC22A6multiple interactionsISOSlc22a6 (Rattus norvegicus)6480464CTDLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]PMID:16925582
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